1,2-Dichloroethane → (+/-)-2-(1,3-Dihydro-2H-isoindol-2-ylcarbonyl)-6,8-dihydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

HRID 2150343Notes

Reaction equation

HRID 2150343 reaction equation
[CH2:26]1[NH:27][CH2:28][c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]21.[CH2:35]([Cl:36])[CH2:37][Cl:38].[CH:49]([N:50]([CH2:51][CH3:52])[CH:53]([CH3:54])[CH3:55])([CH3:56])[CH3:57].[O:1]=[C:2]1[NH:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[C:10]12[CH2:11][c:12]1[c:13]([cH:14][c:15]3[cH:16][cH:17][c:18]([C:22](=[O:23])[OH:24])[n:19][c:20]3[cH:21]1)[CH2:25]2.[O:58]=[CH:59][N:60]([CH3:61])[CH3:62].[OH:39][n:40]1[c:41]2[c:42]([cH:43][cH:44][cH:45][cH:46]2)[n:47][n:48]1>>[O:1]=[C:2]1[NH:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[C:10]12[CH2:11][c:12]1[c:13]([cH:14][c:15]3[cH:16][cH:17][c:18]([C:22](=[O:23])[N:27]4[CH2:26][c:34]5[c:29]([cH:30][cH:31][cH:32][cH:33]5)[CH2:28]4)[n:19][c:20]3[cH:21]1)[CH2:25]2

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 422478IsoindolineHCID 59594282HCID 59594282, compound

Product 1

HCID 17757605(+/-)-2-(1,3-Dihydro-2H-isoindol-2-ylcarbonyl)-6,8-dihydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Sources & evidence

ORD record
ord-47be94e291c840c1921daf8cb208850a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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