Acetic Acid → 2-bromo-6-(trimethylsilyl)pyridine
Reaction equation
[Br:12][c:13]1[n:14][c:15]([Br:19])[cH:16][cH:17][cH:18]1.[CH2:2]([Mg+:3])[CH2:4][CH2:5][CH3:6].[CH2:7]([Li:8])[CH2:9][CH2:10][CH3:11].[CH3:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35].[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[CH3:43][C:44](=[O:45])[OH:46].[Cl-:1].[Cl:20][Si:21]([CH3:22])([CH3:23])[CH3:24].[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1>>[Br:12][c:13]1[n:14][c:15]([Si:21]([CH3:22])([CH3:23])[CH3:24])[cH:16][cH:17][cH:18]1Participants
10
Sources & evidence
- ORD record
- ord-5810b17393b1493199e1aa555f9219a2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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