Methanol → 6-(difluoro(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)-3-(3-morpholinopropoxy)quinoline
Reaction equation
[CH2:81]1[O:82][CH2:83][CH2:84][CH2:85]1.[CH3:76][OH:77].[Cl:78][CH2:79][Cl:80].[F:1][C:2]([c:3]1[cH:4][c:5]2[cH:6][c:7]([OH:13])[cH:8][n:9][c:10]2[cH:11][cH:12]1)([c:14]1[n:15][n:16][c:17]2[n:18]1[cH:19][c:20](-[c:24]1[cH:25][n:26][n:27]([CH3:29])[cH:28]1)[cH:21][c:22]2[F:23])[F:30].[N:60]([C:61]([O:62][C:63]([CH3:64])([CH3:65])[CH3:66])=[O:67])=[N:68][C:69]([O:70][C:71]([CH3:72])([CH3:73])[CH3:74])=[O:75].[OH:50][CH2:51][CH2:52][CH2:53][N:54]1[CH2:55][CH2:56][O:57][CH2:58][CH2:59]1.[c:31]1([P:32]([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[cH:45][cH:46][cH:47][cH:48][cH:49]1>>[F:1][C:2]([c:3]1[cH:4][c:5]2[cH:6][c:7]([O:13][CH2:51][CH2:52][CH2:53][N:54]3[CH2:55][CH2:56][O:57][CH2:58][CH2:59]3)[cH:8][n:9][c:10]2[cH:11][cH:12]1)([c:14]1[n:15][n:16][c:17]2[n:18]1[cH:19][c:20](-[c:24]1[cH:25][n:26][n:27]([CH3:29])[cH:28]1)[cH:21][c:22]2[F:23])[F:30]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-4802ad0bdde14f3987c15651e0b9cbed
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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