Hydrochloric Acid → (+/-)-1-[7-(2-Chlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methanamine

HRID 2154802Notes

Reaction equation

HRID 2154802 reaction equation
[CH3:1][c:2]1[cH:3][cH:4][c:5]([S:6]([O:7][CH2:8][CH:9]2[CH2:10][c:11]3[cH:12][c:13]([F:14])[cH:15][c:16](-[c:17]4[cH:18][cH:19][cH:20][cH:21][c:22]4[Cl:23])[c:24]3[O:25]2)(=[O:26])=[O:27])[cH:28][cH:29]1.[ClH:77].[N-:31]=[N+:32]=[N-:33].[N-:55]=[N+:56]=[N-:57].[N:34](=[N+:35]=[N-:36])[CH2:37][CH:38]1[O:39][c:40]2[c:41]([cH:43][c:44]([F:54])[cH:45][c:46]2-[c:47]2[c:48]([Cl:53])[cH:49][cH:50][cH:51][cH:52]2)[CH2:42]1.[Na+:30].[c:58]1([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[cH:72][cH:73][cH:74][cH:75][cH:76]1>>[NH2:34][CH2:37][CH:38]1[O:39][c:40]2[c:41]([cH:43][c:44]([F:54])[cH:45][c:46]2-[c:47]2[c:48]([Cl:53])[cH:49][cH:50][cH:51][cH:52]2)[CH2:42]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 11776TriphenylphosphineHCID 33558Azide2×HCID 86599116(+/-)-[5-Fluoro-7-(2-chlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonateHCID 86599224(+/-)-2-(Azidomethyl)-7-(2-chlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran

Product 1

HCID 11288935(+/-)-1-[7-(2-Chlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methanamine

Sources & evidence

ORD record
ord-4a00bdcf69f94ccabecf3ca79ba76cc9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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