Imidazole → 2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid [2-(tert-butyldiphenylsilyloxy)-1-methylethyl]amide
Reaction equation
[C:49]([CH3:50])([CH3:51])([CH3:52])[Si:53]([c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1)([c:60]1[cH:61][cH:62][cH:63][cH:64][cH:65]1)[Cl:66].[CH3:68][N:69]([CH3:70])[CH:71]=[O:72].[CH3:73][CH2:74][O:75][C:76](=[O:77])[CH3:78].[OH2:67].[OH:1][CH2:2][CH:3]([CH3:4])[NH:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]2[cH:12][c:13](-[c:25]3[n:26][n:27]([CH2:36][O:37][CH2:38][CH2:39][Si:40]([CH3:41])([CH3:42])[CH3:43])[c:28]4[c:33]3[CH2:32][CH2:31][C:30]([CH3:34])([CH3:35])[CH2:29]4)[n:14]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[c:15]2[cH:16]1.[nH:44]1[cH:45][cH:46][n:47][cH:48]1>>[O:1]([CH2:2][CH:3]([CH3:4])[NH:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]2[cH:12][c:13](-[c:25]3[n:26][n:27]([CH2:36][O:37][CH2:38][CH2:39][Si:40]([CH3:41])([CH3:42])[CH3:43])[c:28]4[c:33]3[CH2:32][CH2:31][C:30]([CH3:34])([CH3:35])[CH2:29]4)[n:14]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[c:15]2[cH:16]1)[Si:53]([C:49]([CH3:50])([CH3:51])[CH3:52])([c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1)[c:60]1[cH:61][cH:62][cH:63][cH:64][cH:65]1Participants
7
Reactant 6
HCID 795Imidazole
HCID 962Water
HCID 6228Dimethylformamide
HCID 8857Ethyl Acetate
HCID 94078tert-Butyldiphenylchlorosilane
HCID 585501082-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid (2-hydroxy-1-methylethyl)amideProduct 1
Sources & evidence
- ORD record
- ord-8d3c56e62dc94263a290c50859848197
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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