Sodium ion → 4-[4-[4-ethyl-1-(2-pyrrolidin-1-ylethyl)imidazol-2-yl]piperidin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one

HRID 2156750Notes

Reaction equation

HRID 2156750 reaction equation
[CH2:1]([CH3:2])[c:3]1[n:4][c:5]([CH:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[n:6]([CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)[cH:7]1.[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[CH3:50][N:51]1[CH2:52][CH2:53][CH2:54][C:55]1=[O:56].[Cl:21][c:22]1[c:23]2[c:24]([n:25][cH:26][n:27]1)[NH:28][C:29](=[O:33])[CH2:30][CH:31]2[CH3:32].[Na+:42].[OH-:41].[OH2:49]>>[CH2:1]([CH3:2])[c:3]1[n:4][c:5]([CH:15]2[CH2:16][CH2:17][N:18]([c:22]3[c:23]4[c:24]([n:25][cH:26][n:27]3)[NH:28][C:29](=[O:33])[CH2:30][CH:31]4[CH3:32])[CH2:19][CH2:20]2)[n:6]([CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)[cH:7]1

Participants

9

Reactant 8

HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 671120884-(4-ethyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidineHCID 866665664-chloro-5-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 671120174-[4-[4-ethyl-1-(2-pyrrolidin-1-ylethyl)imidazol-2-yl]piperidin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one

Sources & evidence

ORD record
ord-e99e9905df5a436faf333de7eac9ac04
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…