Methylamine → HCID 57269820, compound

HRID 21583Notes

Reaction equation

HRID 21583 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7]([C:13](O)=[O:14])=[C:6]2[S:16][CH3:17].[CH3:18][NH2:19].[OH-].[NH4+]>>[CH3:18][NH:19][C:13]([C:7]1[N:8]([CH3:12])[C:9]2[C:5]([C:6]=1[S:16][CH3:17])=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)=[O:14]

Participants

4

Reactant 3

HCID 6329MethylamineHCID 14923Ammonium HydroxideHCID 10848352HCID 10848352, compound

Product 1

HCID 57269820HCID 57269820, compoundYield 45%

Procedure

Prepared from 5-methoxy-1-methyl-3-(methylthio)-1H-indole-2-carboxylic acid by the procedure of Example 1 with 40% aqueous methylamine solution substituted for ammonium hydroxide. Yield 45% after recrystallization from ethyl acetate-hexane; mp 137°-139° C.

Workup

  1. customYield 45% after recrystallization from ethyl acetate-hexane

Sources & evidence

ORD record
ord-39659c9fe2714ece87712ca498ea8311
Source dataset
uspto-grants-1995_06
Patent number
US05424329

Reaction notes

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