反应详情

To a solution of 2,4-dichloroquinazoline (2 g, 10.05 mmol) in THF (50 ml) at 0° C. was added tert-butyl 4-aminopiperidine-1-carboxylate (2.2 g, 11.05 mmol), followed by TEA (2.8 ml, 20.1 mmol) and catalyst DMAP (3 mg). The reaction mixtures was then warmed up to room temperature and stirred for 20 hours. The product was extracted with EtOAc (×2). The organic layers were combined and washed with water, and brine, and dried (MgSO4) and concentrated under vacuum. The product was isolated after silica gel column chromatography using 20% EtOAc and 80% hexane as eluent.

1. customThe reaction mixtures
2. extractionThe product was extracted with EtOAc (×2)
3. washwashed with water, and brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated under vacuum
6. customThe product was isolated after silica gel column chromatography