Tetrahydrofuran → 1-[2-(4-chloro-5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)-1,3-thiazol-5-yl]ethanol

HRID 2159277Notes

Reaction equation

HRID 2159277 reaction equation
[CH3:47][CH2:48][O:49][C:50](=[O:51])[CH3:52].[CH:1]1([S:4](=[O:5])(=[O:6])[c:7]2[cH:8][cH:9][c:10]([CH:13]([CH2:14][CH:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[c:21]3[cH:22][cH:23][c:24](-[c:26]4[s:27][c:28]([CH:31]([CH3:32])[OH:33])[cH:29][n:30]4)[nH:25]3)[cH:11][cH:12]2)[CH2:2][CH2:3]1.[Cl:34][N:35]1[C:36](=[O:37])[CH2:38][CH2:39][C:40]1=[O:41].[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[CH:1]1([S:4](=[O:5])(=[O:6])[c:7]2[cH:8][cH:9][c:10]([CH:13]([CH2:14][CH:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[c:21]3[c:22]([Cl:34])[cH:23][c:24](-[c:26]4[s:27][c:28]([CH:31]([CH3:32])[OH:33])[cH:29][n:30]4)[nH:25]3)[cH:11][cH:12]2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 31398ChlorosuccinimideHCID 25107073HCID 25107073, compound

Product 1

HCID 593314571-[2-(4-chloro-5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)-1,3-thiazol-5-yl]ethanol

Sources & evidence

ORD record
ord-03fb362dd2b0447492ec7a93184a5833
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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