Dimethylformamide → N2-(4-{4-amino-1-[2-(4-methylpiperazino)ethyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1H-2-indolecarboxamide

HRID 2159810Notes

Reaction equation

HRID 2159810 reaction equation
[CH3:1][S:2]([O:3][CH2:6][CH2:7][n:8]1[n:9][c:10](-[c:18]2[cH:19][c:20]([O:37][CH3:38])[c:21]([NH:24][C:25](=[O:26])[c:27]3[n:28]([CH3:36])[c:29]4[cH:30][cH:31][cH:32][cH:33][c:34]4[cH:35]3)[cH:22][cH:23]2)[c:11]2[c:12]1[n:13][cH:14][n:15][c:16]2[NH2:17])(=[O:4])=[O:5].[CH3:39][N:40]1[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]1.[CH3:46][CH2:47][N:48]([CH2:49][CH3:50])[CH2:51][CH3:52].[O:53]=[CH:54][N:55]([CH3:56])[CH3:57]>>[CH2:6]([CH2:7][n:8]1[n:9][c:10](-[c:18]2[cH:19][c:20]([O:37][CH3:38])[c:21]([NH:24][C:25](=[O:26])[c:27]3[n:28]([CH3:36])[c:29]4[cH:30][cH:31][cH:32][cH:33][c:34]4[cH:35]3)[cH:22][cH:23]2)[c:11]2[c:12]1[n:13][cH:14][n:15][c:16]2[NH2:17])[N:43]1[CH2:42][CH2:41][N:40]([CH3:39])[CH2:45][CH2:44]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 531671-MethylpiperazineHCID 223468312-[4-amino-3-(3-methoxy-4-{[(1-methyl-1H-2-indolyl)carbonyl]amino}phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl methanesulfonate

Product 1

HCID 22347346N2-(4-{4-amino-1-[2-(4-methylpiperazino)ethyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1H-2-indolecarboxamide

Sources & evidence

ORD record
ord-d77ae2de052842e4aa4cc2e8944e8043
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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