反应详情

温度

75 °C

To a solution of phthalimide diethylacetal (15 g) in tetrahydrofuran (THF) (30 mL) was added 10% aqueous HCl (18 mL). After heating at 75° C. for 5 hrs, the solution was allowed to cool to RT, and ethyl acetate (100 mL) was added. The solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL), and the organic layer was separated and dried over magnesium sulfate (MgSO4). The solution was filtered and evaporated to provide 11.2 g of the titled compound.

1. temperatureto cool to RT
2. extractionThe solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL)
3. customthe organic layer was separated
4. dry with materialdried over magnesium sulfate (MgSO4)
5. filtrationThe solution was filtered
6. customevaporated