Potassium Cation → 2',4'-Difluoro(1,1'-biphenyl)-4-ol

HRID 2162930Notes

Reaction equation

HRID 2162930 reaction equation
[C:20](=[O:21])([O-:22])[O-:23].[CH:33]1([P:34]([CH:35]2[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]2)[CH:41]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46]2)[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51]1.[CH:52]1([P:53]([CH:54]2[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]2)[CH:60]2[CH2:61][CH2:62][CH2:63][CH2:64][CH2:65]2)[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70]1.[F:1][c:2]1[c:3]([B:9]([OH:10])[OH:11])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[K+:24].[K+:25].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30].[OH2:31].[OH:12][c:13]1[cH:14][cH:15][c:16]([I:17])[cH:18][cH:19]1.[Pd:32]>>[F:1][c:2]1[c:3](-[c:16]2[cH:15][cH:14][c:13]([OH:12])[cH:19][cH:18]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

9

Reactant 8

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 108944-IodophenolHCID 19660Carbonate IonHCID 23938PalladiumHCID 75806Tricyclohexylphosphine2×HCID 27343342,4-Difluorophenylboronic acid

Product 1

HCID 1009552',4'-Difluoro(1,1'-biphenyl)-4-ol

Sources & evidence

ORD record
ord-87c4ea3bc3cb4bafa69601693d898060
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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