Methoxyacetic Acid → HCID 22754110, compound

HRID 2163150Notes

Reaction equation

HRID 2163150 reaction equation
[NH2:1][C:2]1[C:3]([I:19])=[C:4]([C:13]([NH:15][CH2:16][CH2:17][OH:18])=[O:14])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7]([OH:9])=[O:8].[CH3:20][O:21][CH2:22][C:23](Cl)=[O:24].COCC(O)=O.S(Cl)(Cl)=O>CC(N(C)C)=O>[OH:18][CH2:17][CH2:16][NH:15][C:13](=[O:14])[C:4]1[C:5]([I:12])=[C:6]([C:10]([I:11])=[C:2]([NH:1][C:23](=[O:24])[CH2:22][O:21][CH3:20])[C:3]=1[I:19])[C:7]([OH:9])=[O:8]

Participants

6

Reactant 4

HCID 12251Methoxyacetic AcidHCID 24386Thionyl ChlorideHCID 96623Methoxyacetyl chlorideHCID 197775383-Amino-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid

Product 1

HCID 22754110HCID 22754110, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Analogously to Example 1(c), 90.3 g. (150 mmol) of 5-amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid and methoxyacetyl chloride, freshly prepared from 45.5 ml. of methoxyacetic acid/43.5 ml. of thionyl chloride, are reacted in dimethylacetamide; yield: 84.7 g. (84%) m.p. 285° C., with decomposition.

Sources & evidence

ORD record
ord-9916acc7c5b64b7a93f3153c55054044
Source dataset
uspto-grants-1979_01
Patent number
US04132731

Reaction notes

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