1-Bromo-3-chloropropane → 3-(3-chloropropyl)-6,7-dimethoxy-4(3H)-quinazolinone

HRID 2163536Notes

Reaction equation

HRID 2163536 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][NH:7][C:6]2=[O:15].Br[CH2:17][CH2:18][CH2:19][Cl:20].C(Cl)(Cl)Cl.CO>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]([CH2:17][CH2:18][CH2:19][Cl:20])[C:6]2=[O:15]

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 21584188Chloroform methanolHCID 1354950166,7-Dimethoxy-3H-quinazolin-4-one

Product 1

HCID 223266313-(3-chloropropyl)-6,7-dimethoxy-4(3H)-quinazolinone

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-(6,7-Dimethoxy-4-(3H)-quinazolinone-3-yl)-3-chloro-propane was prepared analogous to Example 1 (a) by reaction of 6,7-dimethoxy-4(3H)-quinazolinone with 1-bromo-3-chloro-propane in dimethyl-formamide. Rf -value (chloroform/methanol = 19/1) : 0.75.

Sources & evidence

ORD record
ord-fe7681eaeecc473c830bec2004890d40
Source dataset
uspto-grants-1979_01
Patent number
US04134980

Reaction notes

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