2-Amino-4-methylthiazole → HCID 54684970, compound

HRID 2164111Notes

Reaction equation

HRID 2164111 reaction equation
[CH3:1][N:2]1[C:15]([C:16](OCC2C=CC=CC=2)=[O:17])=[C:14]([OH:26])[C:5]2[N:6]([CH3:13])[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[S:3]1(=[O:28])=[O:27].[NH2:29][C:30]1[S:31][CH:32]=[C:33]([CH3:35])[N:34]=1>C1(C)C(C)=CC=CC=1>[CH3:1][N:2]1[C:15]([C:16]([NH:29][C:30]2[S:31][CH:32]=[C:33]([CH3:35])[N:34]=2)=[O:17])=[C:14]([OH:26])[C:5]2[N:6]([CH3:13])[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[S:3]1(=[O:28])=[O:27]

Participants

4

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 54684959HCID 54684959, compound

Product 1

HCID 54684970HCID 54684970, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

2,5-Dihydro-2,5-dimethyl-4-hydroxy-N-(4-methyl-2-thiazolyl)-1,2-thiazino[5,6-b]indole-3-carboxamide-1,1-dioxide was prepared analogous to Example 2 from benzyl 2,5-dihydro-2,5-dimethyl-4-hydroxy-1,2-thiazino[5,6-b]indole-3-carboxylate-1,1-dioxide and 2-amino-4-methyl-thiazole in xylene; M.p.: 270° C. (decomp.); Yield: 67% of theory;

Sources & evidence

ORD record
ord-257a46ea67a040fbaf6f55581c2d8ac3
Source dataset
uspto-grants-1979_01
Patent number
US04137313

Reaction notes

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