Chlorotrimethylsilane → HCID 22750285, compound

HRID 2164159Notes

Reaction equation

HRID 2164159 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[NH:13][C:14](=[O:21])[C:15](=[CH:19][CH:20]=2)[C:16](O)=O)=[CH:8][CH:7]=1)(=[O:5])=[O:4].O1CCCC1.C[Si]([Cl:31])(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[CH3:1][NH:2][S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[NH:13][C:14](=[O:21])[C:15](=[CH:19][CH:20]=2)[CH2:16][Cl:31])=[CH:8][CH:7]=1)(=[O:5])=[O:4]

Participants

6

Reactant 4

HCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 24386Thionyl ChlorideHCID 22750313HCID 22750313, compound

Product 1

HCID 22750285HCID 22750285, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 5.0 g. of 6-[4-(methylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 250 ml. of tetrahydrofuran, 2.26 ml. of triethylamine, 2.05 ml. of trimethylsilyl chloride and 2.33 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(methylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride.

Sources & evidence

ORD record
ord-9eabe03ad0944e3484651569b7c6a0d0
Source dataset
uspto-grants-1979_01
Patent number
US04137408

Reaction notes

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