4-(Aminosulfonyl)-5-chlorophthalimide → Phthalimide

HRID 2164545Notes

Reaction equation

HRID 2164545 reaction equation
Cl[C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[O:20])[N:7](CCN3CCCCC3)[C:8]2=[O:11])=[CH:4][C:3]=1S(N)(=O)=O.ClC1C=C2C(=O)NC(=O)C2=CC=1S(=O)(=O)N.N1(CCN)CCCCC1>C(O)C>[O:20]=[C:6]1[C:5]2[C:9](=[CH:10][CH:2]=[CH:3][CH:4]=2)[C:8](=[O:11])[NH:7]1

Participants

5

Reactant 3

HCID 197334-(Aminosulfonyl)-5-chlorophthalimideHCID 33944N-(2-Aminoethyl)piperidineHCID 13473187HCID 13473187, compound

Product 1

HCID 6809PhthalimideYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-Chloro-2,3-dihydro-2-[2-(1-piperidinyl)ethyl]-1,3-dioxo-1H-isoindole-5-sulfonamide. Reaction of a mixture of 4-chloro-5-sulfamoylphthalimide and 2-(1-piperidinyl)ethylamine according to the procedure of Example 1(a) afforded a 71% yield of the 1,3-dioxoisoindole intermediate, m.p. 200°-202° from ethanol.

Sources & evidence

ORD record
ord-472f529083b443629aee8941f4a74366
Source dataset
uspto-grants-1985_03
Patent number
US04505911

Reaction notes

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