Triethylamine → HCID 12796234, compound

HRID 2164567Notes

Reaction equation

HRID 2164567 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][C:6]=1[Cl:15])[CH:2]=[CH2:3].Cl.[CH2:17]([O:19][C:20](=[O:23])[CH2:21][NH2:22])[CH3:18].C(N(CC)CC)C.C1CCC(N=C=NC2CCCCC2)CC1>O1CCCC1.C(Cl)(Cl)Cl>[CH2:17]([O:19][C:20](=[O:23])[CH2:21][NH:22][C:12](=[O:14])[CH2:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[C:6]([Cl:15])[CH:7]=1)[CH3:18]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 30951AlclofenacHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 12796234HCID 12796234, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

4-Allyloxy-3-chloro-phenylacetic acid (4.3 g) was dissolved in dry tetrahydrofuran (20 ml). To the solution was added glycine ethyl ester hydrochloride (2.85 g) in dry chloroform (30 ml) containing dry triethylamine (2.8 ml). DCC (4.1 g) was added and the reaction mixture was stirred overnight at room temperature.

Sources & evidence

ORD record
ord-24d1807aa75a4ca9a0e17173b42ba950
Source dataset
uspto-grants-1985_03
Patent number
US04505898

Reaction notes

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