Hydrochloric Acid → HCID 20403330, compound

HRID 2164792Notes

Reaction equation

HRID 2164792 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:4]=[C:5]([S:9]([NH:12][C:13]2[CH:29]=[CH:28][CH:27]=[CH:26][C:14]=2[C:15]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH:25]=[CH:24][N:23]=[CH:22]2)=[O:16])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.[ClH:32]>C(O)(C)C>[ClH:32].[F:30][C:2]([F:1])([F:31])[C:3]1[CH:4]=[C:5]([S:9]([NH:12][C:13]2[CH:29]=[CH:28][CH:27]=[CH:26][C:14]=2[C:15]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH:25]=[CH:24][N:23]=[CH:22]2)=[O:16])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10366593HCID 10366593, compound

Product 1

HCID 20403330HCID 20403330, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-(3-Trifluoromethylbenzenesulphonamido)-N-(3-imidazol-1-ylpropyl)benzamide (9.0 g) was dissolved in hot isopropanol (90 ml). Concentrated aqueous hydrochloric acid (2.0 ml) was added. The resultant solution was evaporated to yield an oil which was recrystallised from ethyl acetate to give 2-(3-trifluoromethylbenzenesulphonamido)-N-(3-imidazol-1-ylpropyl)benzamide hydrochloride (9.3 g) in the form of a white solid, m.p. 173°-175° C.

Workup

  1. customThe resultant solution was evaporated
  2. customto yield an oil which
  3. customwas recrystallised from ethyl acetate

Sources & evidence

ORD record
ord-7fc0e9fa652c4da6a26cdc2fb96a2743
Source dataset
uspto-grants-1985_03
Patent number
US04507315

Reaction notes

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