Trisodium Phosphate → Tyramine

HRID 2165711Notes

Reaction equation

HRID 2165711 reaction equation
P([O-])([O-])([O-])=O.[Na+].[Na+].[Na+].Cl.[NH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1>CC(O)C>[NH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 24243Trisodium PhosphateHCID 66449Tyramine hydrochloride

Product 1

HCID 5610Tyramine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Prepolymer F (low temperature) (5.09 gm, 2.19 meq NCO) was dissolved in 5.0 ml 2-propanol. This solution was added dropwise with stirring to 50.0 ml of 0.05M sodium phosphate (pH 7.0) containing 0.38 gm (2.19 mmoles) tyramine hydrochloride (Sigma Chemical Co.). The resulting turbid solution was stirred for 17 hours at room temperature. A 10.0 ml portion of the product was dialyzed against 500.0 ml water for 46 hours with 4 changes to remove unreacted free tyramine.

Workup

  1. additionThis solution was added dropwise
  2. customA 10.0 ml portion of the product was dialyzed against 500.0 ml water for 46 hours with 4 changes
  3. customto remove unreacted free tyramine

Sources & evidence

ORD record
ord-fa6c5d53d24a4a779eaafb859194817e
Source dataset
uspto-grants-1990_07
Patent number
US04940737

Reaction notes

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