Water → HCID 14209230, compound

HRID 2165831Notes

Reaction equation

HRID 2165831 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][CH2:14][CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[OH:16].C(N(CC)CC)C.O>C(OC(O)C)C>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][CH2:14][CH:15]([OH:16])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 962WaterHCID 1000PhenylethanolamineHCID 68664,7-DichloroquinolineHCID 8471Triethylamine

Product 1

HCID 14209230HCID 14209230, compound

Reagents, catalysts & solvents 1

HCID 101298981-EthoxyethanolSolvent

Procedure

A solution of 4,7-dichloroquinoline (19.8 g), 2-amino-1-phenylethanol (13.7 g) and 20 ml of triethylamine (14.5 g) in 10 ml of ethoxyethanol was heated at 130° C. overnight. The mixture was poured into 600 ml of water and the solid product was collected by filtration recrystallized from ethoxyethanol and washed with ethanol. The yield was 16 g, mp 221°-222° C.

Workup

  1. filtrationthe solid product was collected by filtration
  2. customrecrystallized from ethoxyethanol
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-23bd111840004b6bacf3213ca4800e45
Source dataset
uspto-grants-1990_07
Patent number
US04942168

Reaction notes

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