反应详情

N'-t-butyl-N'-benzoylhydrazine (1 g), benzoyl formic acid (0.7 g) and methanesulfonyl chloride (0.7 g) were stirred in toluene (30 ml) and saturated sodium bicarbonate (10 ml) at approximately 5° C. Triethylamine was added slowly, dropwise to the reaction mixture and stirred 1 hour at room temperature. After stirring for 1 hour, the reaction mixture was diluted with toluene (25 ml) and washed with water several times. The organic layers were dried over magnesium sulfate, filtered and the toluene rotavapped off to afford a white solid. After column chromatography, the product was obtained as a white solid in approximately 70% yield.

1. customat approximately 5° C
2. stirringAfter stirring for 1 hour
3. washwashed with water several times
4. dry with materialThe organic layers were dried over magnesium sulfate
5. filtrationfiltered
6. customto afford a white solid
7. customAfter column chromatography, the product was obtained as a white solid in approximately 70% yield