反应详情

To 150 ml of 2-bromoethanol, 60 g (0.3 mol) of 1,4-dihydroxy-2-naphthoic acid was added, and the reaction was carried out at 90° C. with stirring for 2 hours while introducing hydrogen chloride gas. After being cooled (10°-20° C.), precipitated crystals were separated by filtration to obtain 47.4 g (50% yield) of 1-hydroxy-4-(β-bromoethoxy)-2-naphthoic acid.

1. customwas carried out at 90° C.
2. temperatureAfter being cooled (10°-20° C.)
3. customprecipitated crystals
4. customwere separated by filtration