Water → 4-(2-(2-Methoxyethoxy)ethylthio)-3-nitrobenzenesulfonamide

HRID 2168397Notes

Reaction equation

HRID 2168397 reaction equation
[H-].[Na+].[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][SH:10].F[C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:14][C:13]=1[N+:22]([O-:24])=[O:23].O>O1CCCC1.C(OCC)(=O)C>[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][S:10][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:14][C:13]=1[N+:22]([O-:24])=[O:23]

Participants

7

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 114008022-(2-Methoxyethoxy)ethane-1-thiolHCID 167824874-Fluoro-3-nitrobenzenesulfonamide

Product 1

HCID 671264604-(2-(2-Methoxyethoxy)ethylthio)-3-nitrobenzenesulfonamide

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

In a 100 mL round-bottomed flask was added sodium hydride (0.6 g) in tetrahydrofuran (10 ml) to give a suspension. 2-(2-Methoxyethoxy)ethanethiol (1 g) was added slowly. After the mixture stirred for 30 minutes, 4-fluoro-3-nitrobenzenesulfonamide (1.616 g) in 10 ml tetrahydrofuran was added slowly. After the mixture stirred overnight, water was added slowly, and ethyl acetate (20 ml×3) was used to extract the product. The combined organic layers were dried over Na2SO4. After the mixture was filtered and concentrated, the crude product was added to a silica gel column and purified eluting with 0-10% methanol in dichloromethane.

Workup

  1. customto give a suspension
  2. stirringAfter the mixture stirred overnight
  3. extractionto extract the product
  4. dry with materialThe combined organic layers were dried over Na2SO4
  5. filtrationAfter the mixture was filtered
  6. concentrationconcentrated
  7. additionthe crude product was added to a silica gel column
  8. custompurified
  9. washeluting with 0-10% methanol in dichloromethane

Sources & evidence

ORD record
ord-14d52419a8ad4cacbaefddb1ea554c70
Source dataset
uspto-grants-2015_06
Patent number
US09045420B2

Reaction notes

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