Hydrogen Peroxide → 2-Oxaspiro[3.5]nonane-7-methanol

HRID 2168458Notes

Reaction equation

HRID 2168458 reaction equation
[O:1]1[CH2:5]CC[CH2:2]1.[CH:6]12B[CH:10]([CH2:11][CH2:12][CH2:13]1)[CH2:9][CH2:8]C2.[OH-:15].[Na+].OO>C(O)C>[CH2:2]1[C:12]2([CH2:11][CH2:10][CH:9]([CH2:8][OH:15])[CH2:6][CH2:13]2)[CH2:5][O:1]1

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 789669-Borabicyclo(3.3.1)nonane

Product 1

HCID 671267222-Oxaspiro[3.5]nonane-7-methanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a 25 mL round-bottomed flask was added EXAMPLE 535E (568 mg) and tetrahydrofuran (4.11 mL). 9-Borabicyclo[3.3.1]nonane (0.5 M in tetrahydrofuran, 24.7 mL) was added and the reaction was allowed to stir for 2 hours at room temperature. Ethanol (11 mL) was added followed by aqueous NaOH (5M, 4.11 mL) and then 30% hydrogen peroxide (2.1 mL) was added. The reaction was heated at 50° C. for 2 hours. Most of the ethanol and tetrahydrofuran was removed by rotary evaporation and the residue was diluted with water and ethyl acetate. The aqueous layer was extracted with ethyl acetate (3×) and the combined organics were dried (Na2SO4), filtered and concentrated by rotary evaporation. The residue was purified by regular phase flash column chromatography (Analogix, 0-70% hexanes/ethyl acetate).

Workup

  1. temperatureThe reaction was heated at 50° C. for 2 hours
  2. customMost of the ethanol and tetrahydrofuran was removed by rotary evaporation
  3. additionthe residue was diluted with water and ethyl acetate
  4. extractionThe aqueous layer was extracted with ethyl acetate (3×)
  5. dry with materialthe combined organics were dried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated by rotary evaporation
  8. customThe residue was purified by regular phase flash column chromatography (Analogix, 0-70% hexanes/ethyl acetate)

Sources & evidence

ORD record
ord-f726325e70f54d0497032044dcbd6d34
Source dataset
uspto-grants-2015_06
Patent number
US09045420B2

Reaction notes

Loading…