反应详情

2-(Morpholin-4-yl)pyrimidin-5-ol (300 mg) and ethyl 3-(bromomethyl)-2-fluorobenzoate (850 mg) were mixed with MeCN (5 ml), THF (2 ml) and DMF (1 ml), and potassium carbonate was added thereto, followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and EtOAc and water were then added thereto. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/EtOAc) to obtain ethyl 2-fluoro-3-({[2-(morpholin-4-yl)pyrimidin-5-yl]oxy}methyl)benzoate (378 mg).

1. additionwas added
2. concentrationThe reaction mixture was concentrated under reduced pressure, and EtOAc and water
3. additionwere then added
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated under reduced pressure
6. customThe obtained residue was purified by silica gel column chromatography (hexane/EtOAc)