Potassium Carbonate → HCID 86712405, compound

HRID 2174206Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9]([CH3:14])([CH3:13])[C:10](=[O:12])[CH3:11].Cl[C:16]1[CH:25]=[N:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][C:22]=2[F:26])[N:17]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:16]2[CH:25]=[N:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[F:26])[N:17]=2)[C:3]=1[C:9]([CH3:14])([CH3:13])[C:10](=[O:12])[CH3:11]

Participants

Conditions

Temperature: 100 °C

Procedure

0.32 g of 3-(2-fluoro-6-hydroxy-phenyl)-3-methyl-butan-2-one and 0.28 g of 2-chloro-5-fluoro-quinoxaline were dissolved in 3 ml of dimethylformamide. 0.25 g of potassium carbonate were added thereto followed by stirring for 2 hours at 100° C. Subsequently, the reaction mixture was purified by silica gel column chromatography to obtain 0.14 g of 3-[2-fluoro-6-(5-fluoro-quinoxalin-2-yloxy)-phenyl]-3-methyl-butan-2-one.

Workup

customSubsequently, the reaction mixture was purified by silica gel column chromatography

Sources & evidence

ORD record: ord-3ec1853e12804aa5833eb4e18af1fbe0
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09060517B2

Reaction notes

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