Potassium Carbonate → HCID 86712407, compound

HRID 2174208Notes

Reaction equation

HRID 2174208 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([F:14])[C:8]=2[F:13])[N:3]=1.[CH3:15][O:16][C:17]([C:20]1[C:25]([OH:26])=[CH:24][CH:23]=[CH:22][N:21]=1)([CH3:19])[CH3:18].C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[F:13][C:8]1[C:7]([F:14])=[CH:6][CH:5]=[C:4]2[C:9]=1[N:10]=[C:11]([CH3:12])[C:2]([O:26][C:25]1[C:20]([C:17]([O:16][CH3:15])([CH3:18])[CH3:19])=[N:21][CH:22]=[CH:23][CH:24]=1)=[N:3]2

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 86712408HCID 86712408, compoundHCID 86712409HCID 86712409, compound

Product 1

HCID 86712407HCID 86712407, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
100 °C

Procedure

0.17 g of 2-chloro-5,6-difluoro-3-methylquinoxaline were dissolved in 2 mL of N-methylpyrrolidone. 0.13 g of 2-(1-methoxy-1-methyl-ethyl)-pyridin-3-ol and 0.11 g of potassium carbonate were added thereto followed by stirring for 3 hours at 100° C. Subsequently, the reaction solution was purified by silica gel column chromatography to obtain 0.24 g of 5,6-difluoro-2-[2-(1-methoxy-1-methyl-ethyl)-pyridin-3-yloxy]-3-methyl-quinoxaline.

Workup

  1. customSubsequently, the reaction solution was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-5eaef84c74074d828f5489e30dd3434c
Source dataset
uspto-grants-2015_06
Patent number
US09060517B2

Reaction notes

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