Diisopropylethylamine → HCID 59452233, compound

HRID 2174703Notes

Reaction equation

HRID 2174703 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[N:11]=2)=[CH:4][CH:3]=1.[CH:15]1([N:18]2[CH2:24][CH2:23][C:22]3[CH:25]=[C:26]([NH2:29])[CH:27]=[CH:28][C:21]=3[CH2:20][CH2:19]2)[CH2:17][CH2:16]1.CCN(C(C)C)C(C)C>C1(C)C=CC=CC=1.C(O)(=O)C.CN(C=O)C>[CH:15]1([N:18]2[CH2:24][CH2:23][C:22]3[CH:25]=[C:26]([NH:29][C:9]([C:10]([NH:11][C:7]([C:5]4[S:6][C:2]([Cl:1])=[CH:3][CH:4]=4)=[O:8])([CH3:13])[CH3:12])=[O:14])[CH:27]=[CH:28][C:21]=3[CH2:20][CH2:19]2)[CH2:16][CH2:17]1

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 45123180HCID 45123180, compoundHCID 58290013HCID 58290013, compound

Product 1

HCID 59452233HCID 59452233, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 18331056Acetic acid tolueneSolvent

Conditions

Temperature
80 °C

Procedure

200.0 μl (10.0 μmol) of a 0.05 molar 2-(5-chloro-thiophen-2-yl)-4,4-dimethyl-4H-oxazol-5-one solution in toluene/acetic acid 9:1 are combined with 200.0 μl (10.0 μmol) of a 0.05-molar 3-cyclopropyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine solution in DMF and 1.7 μl (10.0 μmol) DIPEA, heated to 80° C. overnight and left to stand for 2 days at room temperature. The reaction solution is filtered through basic aluminium oxide and the filtrate is evaporated down i. vac.

Workup

  1. waitleft
  2. filtrationThe reaction solution is filtered through basic aluminium oxide
  3. customthe filtrate is evaporated down i

Sources & evidence

ORD record
ord-49a84130ed814cefb0ef9a5208b38199
Source dataset
uspto-grants-2015_06
Patent number
US09062034B2

Reaction notes

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