反应详情

1.30 g (4.27 mmol) 2,2,2-trifluoro-1-(7-hydroxy-8-nitro-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethanone are placed in 20 ml DMF and at room temperature 0.65 g (4.70 mmol) potassium carbonate and 0.508 ml (4.27 mmol) benzylbromide are added and the mixture is stirred for 3 h. Then it is filtered and the filtrate is concentrated by evaporation i.vac., the residue is triturated with water, suction filtered and dried at 45° C. in the circulating air dryer.

1. additionare added
2. filtrationThen it is filtered
3. concentrationthe filtrate is concentrated by evaporation i.vac
4. custom, the residue is triturated with water, suction
5. filtrationfiltered
6. customdried at 45° C. in the circulating air dryer