反应详情

温度

100 °C

To a solution of (R)-3-(2-cyclopropyl-8-oxo-7,8-dihydro-purin-9-yl)-3-phenyl-propionic acid ethyl ester (313 mg, 0.89 mmol) in DMF (5 ml) were added K2CO3 (234 mg, 1.7 mmol) and (1,4-Dimethyl-1H-indol-3-ylmethyl)-trimethyl-ammonium iodide (275 mg, 1.27 mmol). The reaction mixture was heated to 100° C. for 4 hours. The reaction mixture was therefore diluted with ethyl acetate and washed with water (×4). The organic phase was dried over MgSO4 and concentrated. The resulting residue was purified by chromatography, eluded with 3% methanol to 10% in CH2Cl2 to afford the titled compound (231 mg, 50%). LCMS, M++1, m/z: 509.59.

1. washwashed with water (×4)
2. dry with materialThe organic phase was dried over MgSO4
3. concentrationconcentrated
4. customThe resulting residue was purified by chromatography