反应详情

温度

0 °C

A rapidly stirred mixture of ethyl acetate and saturated aqueous sodium bicarbonate containing commercially available commercially available 2 ethyl 2-(methylamino)acetate (1.91 g, 12.4 mmol, HCl salt) was cooled to 0° C. and treated dropwise with benzyl chloroformate (4.10 mL, 12.3 mmol). After stirring overnight warming to room temperature, the aqueous layer was removed and the organic layer concentrated in vacuo. Purification of the residue by flash chromatography (silica gel, DCM) yielded the product.

1. temperaturewarming to room temperature
2. customthe aqueous layer was removed
3. concentrationthe organic layer concentrated in vacuo
4. customPurification of the residue by flash chromatography (silica gel, DCM)
5. customyielded the product