Hydrochloric Acid → HCID 90411401, compound

HRID 2175960Notes

Reaction equation

HRID 2175960 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH2:8][CH:9]2[CH2:14][CH:13]3[N:15](C(OC(C)(C)C)=O)[CH:10]2[CH2:11][CH2:12]3)[N:2]=1.[ClH:23]>O1CCOCC1.CC(O)C>[ClH:23].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH2:8][CH:9]2[CH2:14][CH:13]3[NH:15][CH:10]2[CH2:11][CH2:12]3)[N:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90412485HCID 90412485, compound

Product 1

HCID 90411401HCID 90411401, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

To the title compound from step A (300 mg, 1 mmol) in 1,4-dioxane (3 mL) was added 6N HCl in iPrOH (1 mL). The reaction was heated to 70° C. for 3 h, cooled to rt and concentrated to give the title compound that was used without further purification. MS (ESI) mass calcd. for C11H15N3O, 205.1; m/z found 206.0 [M+H]+.

Workup

  1. temperaturecooled to rt
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-fe9ff343efd24e1984fcf36ddd9f905e
Source dataset
uspto-grants-2015_06
Patent number
US09062078B2

Reaction notes

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