Hydrochloric Acid → HCID 90411982, compound

HRID 2175969Notes

Reaction equation

HRID 2175969 reaction equation
[F:1][C:2]1[CH:3]=[N:4][C:5]([O:8][CH2:9][CH:10]2[CH2:15][CH:14]3[N:16](C(OC(C)(C)C)=O)[CH:11]2[CH2:12][CH2:13]3)=[N:6][CH:7]=1.Cl>O1CCOCC1.CC(O)C>[F:1][C:2]1[CH:3]=[N:4][C:5]([O:8][CH2:9][CH:10]2[CH2:15][CH:14]3[NH:16][CH:11]2[CH2:12][CH2:13]3)=[N:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90412916HCID 90412916, compound

Product 1

HCID 90411982HCID 90411982, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
40 °C

Procedure

To the title compound from step A (474 mg, 1.5 mmol) in 1,4-dioxane (1.5 mL) was added 6N HCl in iPrOH (1.5 mL). The reaction was heated to 40° C. for 1.5 h and concentrated to give the title compound that was used without further purification in subsequent steps. MS (ESI) mass calcd. for C11H14FN3O, 223.1; m/z found 224.0 [M+H]+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-45e6c8c823da4ba0873d26483468d182
Source dataset
uspto-grants-2015_06
Patent number
US09062078B2

Reaction notes

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