Hydrochloric Acid → HCID 90413051, compound

HRID 2175977Notes

Reaction equation

HRID 2175977 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[NH:11][CH:12]1[CH2:17][CH:16]2[N:18](C(OC(C)(C)C)=O)[CH:13]1[CH2:14][CH2:15]2.[ClH:26]>O1CCOCC1.CC(O)C>[ClH:26].[CH:13]12[NH:18][CH:16]([CH2:15][CH2:14]1)[CH2:17][CH:12]2[NH:11][C:2]1[CH:3]=[N:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90411630HCID 90411630, compound

Product 1

HCID 90413051HCID 90413051, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

To the title compound from step A (343 mg, 1 mmol) in 1,4-dioxane (10 mL) was added 6N HCl in iPrOH (1 mL). The reaction was heated to 70° C. for 2 h, cooled to rt, concentrated and used without further purification in subsequent steps.

Workup

  1. temperaturecooled to rt
  2. concentrationconcentrated
  3. customused without further purification in subsequent steps

Sources & evidence

ORD record
ord-89daacb7ed8640e48ff452cd6c1fd81b
Source dataset
uspto-grants-2015_06
Patent number
US09062078B2

Reaction notes

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