Potassium Carbonate → HCID 90370050, compound

HRID 2176008Notes

Reaction equation

HRID 2176008 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:39]=[CH:40][CH:41]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[CH2:38][CH2:37][CH2:36][CH2:35][C:12]=2[C:13]=1[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]2[CH:34]=[CH:33][C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:27][CH:26]=2)=[CH:19][CH:18]=1)=[O:15])=[O:7].[C:42]([O:46][C:47](=[O:55])[NH:48][CH2:49][CH2:50][NH:51][CH:52]1[CH2:54][CH2:53]1)([CH3:45])([CH3:44])[CH3:43].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:42]([O:46][C:47]([NH:48][CH2:49][CH2:50][N:51]([CH2:2][C:3]1[CH:4]=[C:5]([CH:39]=[CH:40][CH:41]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[CH2:38][CH2:37][CH2:36][CH2:35][C:12]=2[C:13]=1[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]2[CH:34]=[CH:33][C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:27][CH:26]=2)=[CH:19][CH:18]=1)=[O:15])=[O:7])[CH:52]1[CH2:53][CH2:54]1)=[O:55])([CH3:45])([CH3:43])[CH3:44]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 45091939Carbamic acid, [2-(cyclopropylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)HCID 90370193HCID 90370193, compound

Product 1

HCID 90370050HCID 90370050, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using 2.0 g of methyl 4-[2-(4-{[(2-{[3-(chloromethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate, 1.0 g of tert-butyl[2-(cyclopropylamino)ethyl]carbamate, 0.76 g of potassium carbonate, and 40 mL of DMF, 2.5 g of methyl 4-(2-{4-[({2-[(3-{[{2-[(tert-butoxycarbonyl)amino]ethyl}(cyclopropyl)amino]methyl}benzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophen-3-yl}carbonyl)amino]phenyl}ethyl)benzoate was obtained by the method similar to Preparation Example 9.

Sources & evidence

ORD record
ord-b2904962d1a048679ab0dfb83fba3272
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

Loading…