2,6-Dimethylaniline → HCID 792040, compound

First, 13.8 g of 2,6-dimethylaniline, 17.3 g of triethylamine, and 150 mL of tetrahydrofuran (THF) were put in a 500 mL three-neck flask, and stirred. This mixed solution was cooled in ice, and a mixed solution of 25 g of 3-bromobenzoyl chloride and 30 mL of THF was dripped through a dropping funnel, and then, the temperature was increased to room temperature and the mixture was stirred for 24 hours. After the stirring, chloroform was added to this mixture, the mixture was washed with water and then saturated saline, and anhydrate magnesium sulfate was added for drying. The mixture after the drying was subjected to gravity filtration, and the filtrate was concentrated to give a solid. This solid was washed with hexane, so that N-(2,6-dimethylphenyl)-3-bromobenzamide was prepared as a white solid with a yield of 53%. The synthetic scheme of Step 1 is shown by (a-17).

1. temperatureThis mixed solution was cooled in ice
2. stirringthe mixture was stirred for 24 hours
3. washthe mixture was washed with water
4. additionsaturated saline, and anhydrate magnesium sulfate was added
5. customfor drying
6. filtrationThe mixture after the drying was subjected to gravity filtration
7. concentrationthe filtrate was concentrated
8. customto give a solid
9. washThis solid was washed with hexane, so that N-(2,6-dimethylphenyl)-3-bromobenzamide
10. customwas prepared as a white solid with a yield of 53%

ORD record

ord-6b1837f05ed6462389cbefac2778823b

Source dataset

uspto-grants-2015_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09065061B2