反应详情

温度

70 °C

To a solution of 2,6-difluorobenzonitrile (100 mg; 0.72 mmol) and 4-chloro-2-methoxyphenol (114 mg; 0.72 mmol) in anhydrous DMF (5 mL) is added potassium carbonate (50 mg; 0.36 mmol). The reaction mixture is heated to 70° C. overnight. After allowing to room temperature, the solvent is removed under vacuum and the resulting solid is partitioned between ethyl acetate and water. The organics are separated and dried over magnesium sulfate. The solvent is removed to give 145 milligrams of 2-(4-chloro-2-methoxyphenoxy)-6-fluorobenzonitrile.

1. customAfter allowing to room temperature
2. customthe solvent is removed under vacuum
3. customthe resulting solid is partitioned between ethyl acetate and water
4. customThe organics are separated
5. dry with materialdried over magnesium sulfate
6. customThe solvent is removed