反应详情

温度

110 °C

Thiophenol (0.128 ml) was added to a mixture of 6-ethyl-3H-isobenzofuran-1-one (Intermediate 18, 0.202 g) and potassium carbonate (0.344 g) in dry DMF (1.3 ml). The resultant mixture was stirred and heated at 110° C. for 2 hours. After cooling, the mixture was diluted with water and acidified by addition of hydrochloric acid (1M). The resultant solid was collected by filtration, washed with water and dried under vacuum to give 2-(phenylthiomethyl)-5-ethylbenzoic acid (0.288 g) as a white solid.

1. temperatureAfter cooling
2. filtrationThe resultant solid was collected by filtration
3. washwashed with water
4. customdried under vacuum