Hydrochloric Acid → HCID 58065593, compound

HRID 217792Notes

Reaction equation

HRID 217792 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[NH2:6][C:7]1[C:8]([C:26]([NH:28][C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)=[O:27])=[N:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][CH2:22][CH2:23][O:24][CH3:25])=[CH:15][CH:14]=2)=[CH:11][N:12]=1.[ClH:35]>CC#N>[NH2:6][C:7]1[C:8]([C:26]([NH:28][C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)=[O:27])=[N:9][C:10]([C:13]2[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][NH:21][CH2:22][CH2:23][O:24][CH3:25])=[CH:17][CH:18]=2)=[CH:11][N:12]=1.[ClH:35].[ClH:35].[ClH:35].[NH2:6][C:7]1[C:8]([C:26]([NH:28][C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)=[O:27])=[N:9][C:10]([C:13]2[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][NH:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:17][CH:18]=2)=[CH:11][N:12]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 80182-MethoxyethylamineHCID 58065593HCID 58065593, compound

Product 2

HCID 58065593HCID 58065593, compoundHCID 66678673HCID 66678673, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-Amino-6-(4-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide was prepared using analogous procedures to those described in Example 6, except that 2-methoxyethylamine was used instead of 3-methoxypropylamine in step (v). MeCN was added to 3-Amino-6-(4-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide and 0.5 M-aqueous HCl (20 mL) was also added. The resulting yellow solution was then lyophilized, which afforded the title compound as a tri-hydrochloride salt.

Workup

  1. additionwas also added

Sources & evidence

ORD record
ord-fd8cbd0b49e74d47b1d810a7e41f664c
Source dataset
uspto-grants-2012_06
Patent number
US08198285B2

Reaction notes

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