反应详情

To a 50 mL round-bottomed flask were added a stir bar, 2-nitro-4-(quinolin-2-ylmethoxy)-N-(4-(trifluoromethyl)benzyl)aniline (310 mg, 0.69 mmol), THF (6.9 mL), and DIPEA (60 μL, 0.3 mmol) followed by 5% platinum on carbon (15 mg, 0.08 mmol). The reaction vessel was evacuated and then placed under one atmosphere of hydrogen for 16 h. The mixture was then flushed with N2 and filtered through a pad of Celite. The Celite was then rinsed with additional THF (25 mL). The resulting solution was concentrated to dryness to afford the title compound which was used without further purification. MS (ESI): mass calcd. for C24H20F3N3O, 423.16; m/z found, 424.1 [M+H]+.

1. additionTo a 50 mL round-bottomed flask were added a stir bar
2. customThe reaction vessel was evacuated
3. customThe mixture was then flushed with N2
4. filtrationfiltered through a pad of Celite
5. washThe Celite was then rinsed with additional THF (25 mL)
6. concentrationThe resulting solution was concentrated to dryness