Water → HCID 69799515, compound

HRID 2179982Notes

Reaction equation

HRID 2179982 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[O:9][C@@H:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:11][CH2:12]I.[NH2:20][CH2:21][CH2:22][CH2:23][OH:24].O>CN(C)C=O>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[O:9][C@@H:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:11][CH2:12][NH:20][CH2:21][CH2:22][CH2:23][OH:24]

Participants

5

Reactant 3

HCID 962WaterHCID 90863-Amino-1-propanolHCID 69799252HCID 69799252, compound

Product 1

HCID 69799515HCID 69799515, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product of step (b) (0.2 g) and 3-amino-propanol (0.11 g) were dissolved in dimethylformamide (4 ml) and stirred for 24 h. The reaction was poured into water and extracted into ethyl acetate. The organic extract was washed with brine, dried over magnesium sulphate and evaporated to dryness and triturated with 1N HCl in ether to give the product as a white solid.

Workup

  1. extractionextracted into ethyl acetate
  2. extractionThe organic extract
  3. washwas washed with brine
  4. dry with materialdried over magnesium sulphate
  5. customevaporated to dryness
  6. customtriturated with 1N HCl in ether

Sources & evidence

ORD record
ord-99a4545c79eb4df79264a21932f1e55c
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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