反应详情

2.0 g (7.8 mmol) of 4-(3-acetylaminophenyl)piperidine hydrochloride was dissolved in 20 ml of N,N-dimethylformamide, and then 1.3 g (10.2 mmol) of 2-bromoethanol and 3.2 g (23.4 mmol) of K2CO3 were added to the resulting solution, followed by treating the mixture at 60° C. for 5 hours. The reaction mixture was combined with 100 ml of water and extracted with ethylacetate (70 ml×5), and then the combined organic layer was dried over anhydrous sodium sulfate, and filtered. The solvent was removed from the filtrate under a reduced pressure, and the resulting residue was refined by silica gel column chromatography (10% methanol/CH2Cl2) to obtain 1.14 g (yield 56%) of the title compound.

1. additionby treating the mixture at 60° C. for 5 hours
2. extractionextracted with ethylacetate (70 ml×5)
3. dry with materialthe combined organic layer was dried over anhydrous sodium sulfate
4. filtrationfiltered
5. customThe solvent was removed from the filtrate under a reduced pressure