Potassium Carbonate → 3-Fluoro-5-[(3-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine

HRID 2181896Notes

Reaction equation

HRID 2181896 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]([NH:17][S:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[CH:22]=1)(=[O:20])=[O:19])[CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:8][C:6]1[CH:7]=[CH:2][C:3]2[C:9]3[C:10]([CH:15]([CH3:16])[N:17]([S:18]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[CH:22]=4)(=[O:20])=[O:19])[C:4]=2[CH:5]=1)=[CH:11][CH:12]=[CH:13][CH:14]=3

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22482284N-[1-(2',4'-Difluoro-1,1'-biphenyl-2-yl)ethyl]-3-methoxybenzenesulfonamide

Product 1

HCID 224822573-Fluoro-5-[(3-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from N-[1-(2′,4′-difluoro-1,1′-biphenyl-2-yl)ethyl]-3-methoxybenzenesulfonamide (454 mg, 1.12 mmol), anhydrous N,N-dimethylformamide (2 mL), and potassium carbonate (311 mg, 2.25 mmol) according to the procedure and in the same manner as described in Example 105, step d, and the product (426 mg, 99%) isolated as a white solid, m.p. 115-117° C.;

Sources & evidence

ORD record
ord-c557c777ba85484a87c80cc3cb45e19d
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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