Hydrochloric Acid → HCID 59075088, compound

HRID 2184336Notes

Reaction equation

HRID 2184336 reaction equation
C([O:3][C:4](=[O:33])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C@@H:12]1[CH2:17][CH2:18][CH:19]([OH:32])[C:20]1[O:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:31])=[CH:23][CH:24]=1)C.[OH-].[Na+].Cl.C(OCC)(=O)C>CO>[OH:32][CH:19]([C:20]1[O:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:31])=[CH:23][CH:24]=1)[CH2:18][CH2:17][C@H:12]1[CH2:13][CH2:14][C:15](=[O:16])[N:11]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:33])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 69547056HCID 69547056, compound

Product 1

HCID 59075088HCID 59075088, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The ester (54 mg) was dissolved in methanol (3 mL) and treated with 5 M aqueous solution of sodium hydroxide (0.5 mL) and stirred at ambient temperature for 1 hour. 7-{(S)-2-[3-hydroxy-3-(5-o-tolyl-furan-2-yl)-propyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid (54) (71) (45 mg, 0.10 mmol) resulted upon treatment with 1 M aqueous hydrochloric acid and extraction with ethyl acetate: MS: 428 [(M+H)+].

Sources & evidence

ORD record
ord-06f862ec8a264e738456efb8269b0b4a
Source dataset
uspto-grants-2005_05
Patent number
US06900336B2

Reaction notes

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