Hydrochloric Acid → HCID 21340317, compound

HRID 2184639Notes

Reaction equation

HRID 2184639 reaction equation
Cl.[C:2]([C@@:19]([C:26]([OH:28])=[O:27])([CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])[NH2:20])([O:4][CH2:5][CH:6]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2)=[O:3].Cl>CN(C=O)C.N1C=CC=CC=1>[C:2]([C@@:19]([C:26]([OH:28])=[O:27])([CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])[NH2:20])([O:4][CH2:5][CH:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:13]2[C:18]1=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21340318HCID 21340318, compound

Product 1

HCID 21340317HCID 21340317, compoundYield 106%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6228DimethylformamideSolvent

Procedure

To 0.41 g of Compound 24 in 10 mL of DMF and 3 mL of pyridine at room temperature is added 0.57 g of α-FMOC-L-lysine hydrochloride. The mixture is stirred at room temperature for three days, followed by warming at 35° C. for 30 minutes. The solution is poured into 130 mL of cold 1 M HCl. The crude residue is filtered and dried in vacuo then purified on a silica gel column to yield 0.55 g of the α-FMOC-L-lysine 25.

Workup

  1. temperatureby warming at 35° C. for 30 minutes
  2. filtrationThe crude residue is filtered
  3. customdried in vacuo
  4. customthen purified on a silica gel column

Sources & evidence

ORD record
ord-eceedb0563e04dbcbfb2574982a7e64c
Source dataset
uspto-grants-2002_06
Patent number
US06399392B1

Reaction notes

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