反应详情

温度

-18 °C

Pieces of sodium (3.678 g, 160 mmol) were added portionwise to ethanol (200 ml) over a period of 30 minutes. The resulting solution was cooled to −18° C. and a mixture of 2-methoxybenzaldehyde (4.832 g, 40 mmol) and ethyl azidoacetate (160 mmol) were then added over a period of one hour at a rate which allowed the temperature to be maintained below −15° C. After 3 hours, the solution was stored at 5° C. for 2 days in order to give a crystalline product which was collected by filtration and washed with cold hexane.

1. additionwere then added over a period of one hour at a rate which
2. temperatureto be maintained below −15° C
3. waitthe solution was stored at 5° C. for 2 days in order
4. customto give a crystalline product which
5. filtrationwas collected by filtration
6. washwashed with cold hexane