反应详情

温度

0 °C

Under a nitrogen atmosphere in a flame-dried flask, sodium hydride (72 mg, 1.79 mmol, 60% oil dispersion) was washed with hexanes and then treated with 6 mL of anhydrous DMF, and cooled to 0° C. Thiomorpholin-3-one (200 mg, 1.71 mmol) was added in one portion with stirring. After gas evolution had stopped (ca. 30 min), 4-iodo-1,2-dichlorobenzene (700 mg, 2.56 mmol) was added, followed after 5 minutes by copper (I) bromide (490 mg, 3.42 mmol). After heating at 75° C. overnight, the mixture was partitioned between ethyl acetate and 1 N lithium chloride, filtered through diatomaceous earth and combined with additional ethyl acetate washes of the diatomaceous earth filter cake. The organic layers were washed with additional 1 N lithium chloride, brine (saturated sodium chloride) and dried over calcium sulfate (CaSO4). Concentration in vacuo gave 363 mg of light brown oil which was flash chromatographed (30-50% ethyl acetate in hexanes) to give a white solid, 108 mg.

1. additionwas added
2. temperatureAfter heating at 75° C. overnight
3. customthe mixture was partitioned between ethyl acetate and 1 N lithium chloride
4. filtrationfiltered through diatomaceous earth
5. filtrationfilter cake
6. washThe organic layers were washed with additional 1 N lithium chloride, brine (saturated sodium chloride)
7. dry with materialdried over calcium sulfate (CaSO4)
8. concentrationConcentration in vacuo