Benzyl chloroformate → HCID 23713430, compound

HRID 2186309Notes

Reaction equation

HRID 2186309 reaction equation
[H-].[Na+:2].[OH-].[OH-].[OH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([O-:15])(=[O:14])=[O:13])=[CH:8][CH:7]=1.[Na+].Cl[C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19]>O1CCCC1>[CH2:21]([O:20][C:18]([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([O-:15])(=[O:13])=[O:14])=[CH:8][CH:7]=1)=[O:19])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[Na+:2]

Participants

5

Reactant 3

HCID 10387Benzyl chloroformateHCID 24758Sodium hydrideHCID 22456370HCID 22456370, compound

Product 1

HCID 23713430HCID 23713430, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

To an aqueous solution (40 ml) of sodium hydride (3.8 g), sodium 4-hydroxybenzenesulfonate dihydroxide (20 g) and tetrahydrofuran (28 ml) was added. To the mixture, benzyl chloroformate (12.3 ml) was added at 0° C. The mixture was stirred for 1 hour at 0° C. and for 1 hour at room temperature. The reaction mixture was concentrated. The precipitated crystals was washed with water and dried to give the title compound (18.1 g) having the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washThe precipitated crystals was washed with water
  3. customdried

Sources & evidence

ORD record
ord-5345771b034f4ecd853b9ca5456a82ca
Source dataset
uspto-grants-2002_06
Patent number
US06403644B1

Reaction notes

Loading…