反应详情

温度

0 °C

In a 100 ml four-necked flask were charged 6.0 g (34.6 mmol) of ethyl (R)-4-azido-3-hydroxybutyrate, 4.2 g (41.5 mmol) of triethylamine, 0.12 g (1.04 mmol) of 4-dimethylaminopyridine, and 60 ml of tetrahydrofuran and the mixture was cooled to 0° C. 5.10 g (38.1 mmol) of hexanoyl chlrodie was slowly added thereto dropwise in a nitrogen stream. After the addition, the reaction mixture was stirred at a room temperature for 5 hours, and then 14 ml of 5% HCL was added thereto. After the liquid separation, the mixture was washed thrice with 30 ml of 5% aqueous solution of sodium chloride and then concentrated to give 8.75 g (93%) of the title compound.

1. addition5.10 g (38.1 mmol) of hexanoyl chlrodie was slowly added
2. additionAfter the addition
3. addition14 ml of 5% HCL was added
4. customAfter the liquid separation
5. washthe mixture was washed thrice with 30 ml of 5% aqueous solution of sodium chloride
6. concentrationconcentrated